ScoutIndex

SF SF

Isaac Guerendo

RB

A 4th-round pick (129th overall) in the 2024 NFL Draft out of Louisville; Wisconsin, Isaac Guerendo has built an NFL career since. He's currently with SF, in his 3rd season in the league. His speed stands out most — the 97th percentile at the position. Across 2 NFL seasons, he has totaled 420 rushing yards and 4 touchdowns.

Size

6'0", 221#

College

Louisville; Wisconsin

Draft

Rd 4, 129th overall (2024)

Seasons

2024–2026

2025 ScoutIndex Rating · RB

Methodology
51.5

60th percentile among RBs · limited sample

7 games · 0 touches

Volume×0.1-0.87
Receiving×0.14+0.24
Total EPA×0.24+0.33
Conversion×0.1+0.01
Ball security×0.06+0.02
Yards/carry×0.12+0.10
Rush EPA/carry×0.24+0.09

Week 1 projection · @ LAR

Methodology
Rush yds20.9 (3–38.8)51% 20.5+
Rush yds20.9 (3–38.8)51% 20.5+
Rush yds20.9 (3–38.8)51% 20.5+
Rush yds20.9 (3–38.8)51% 20.5+
Rush yds20.9 (3–38.8)51% 20.5+
Rush yds20.9 (3–38.8)51% 20.5+
Rush TD0.1 (0–1)10% 0.5+
Rush TD0.1 (0–1)10% 0.5+
Rush TD0.1 (0–1)10% 0.5+
Rush TD0.1 (0–1)10% 0.5+
Rush TD0.1 (0–1)10% 0.5+
Rush TD0.1 (0–1)10% 0.5+
Rec1.6 (0–3)47% 1.5+
Rec1.6 (0–3)47% 1.5+
Rec1.6 (0–3)47% 1.5+
Rec1.6 (0–3)47% 1.5+
Rec1.6 (0–3)47% 1.5+
Rec1.6 (0–3)47% 1.5+
Rec yds21.6 (3.7–39.6)53% 20.5+
Rec yds21.6 (3.7–39.6)53% 20.5+
Rec yds21.6 (3.7–39.6)53% 20.5+
Rec yds21.6 (3.7–39.6)53% 20.5+
Rec yds21.6 (3.7–39.6)53% 20.5+
Rec yds21.6 (3.7–39.6)53% 20.5+

Mean (10th–90th percentile) · recent form × matchup. Informational, not wagering advice.

2025 attribute card

click a row to see the formula
AthleticismRushingReceivingImpact

group averages

Athleticism

Speed97▶

Percentile of 40-yard dash time among RBs at the NFL Combine (faster = higher), 2000–present.

Burst97▶

Percentile of vertical jump + broad jump among combine RBs.

Agility74▶

Percentile of 3-cone + short shuttle among combine RBs (faster = higher).

Size76▶

Height/weight z-score vs. the RB cohort (from official bio, not combine-dependent).

Rushing

Rush Efficiency58▶

Rushing EPA ÷ carry.

Yards/Carry61▶

Rushing yards ÷ carry.

Conversion53▶

(Rushing first downs + ½ rushing TD) ÷ carry.

Receiving

Receiving76▶

Receiving EPA ÷ target, plus a reception-volume bonus — the same formula behind the Rating's receiving component.

Impact

Ball Security28▶

Fumbles lost ÷ touch (fewer is better).

Volume4▶

Carries + receptions this season.

Efficiency70▶

Total EPA (rushing + receiving) per game.

Career (regular season)

SeasonTmSIGPass ydsPass TDRush ydsRush TDRecRec ydsRec TD
2025SF51.57
2024SF65.616420415152

Career profile

Isaac Guerendo has appeared in 23 regular-season games across 2 NFL seasons on file, all with SF.

He has rushed for 420 yards and 4 touchdowns. As a receiver he has caught 15 passes for 152 yards and 0 touchdowns. His most productive rushing season was 2024 with SF: 420 yards and 4 touchdowns in 16 games.

Career highs (regular season)

2025 splits

regular season

2025 game log

WkOppLineScore
Week 1SEA—49.3
Week 2NO—47.8
Week 3ARI—49.2
Week 5LAR—48.5
Week 7ATL—48.6
Week 9NYG—47.9
Week 13CLE—48

Isaac Guerendo — common questions

What position does Isaac Guerendo play?
Isaac Guerendo is listed as an RB.
Which teams has Isaac Guerendo played for?
In the seasons on file (1999 onward), Isaac Guerendo has played for SF (2024–2025).
Where did Isaac Guerendo go to college?
Isaac Guerendo played college football at Louisville; Wisconsin.
When was Isaac Guerendo drafted?
Isaac Guerendo was selected in round 4, 129th overall, of the 2024 NFL Draft.
How many touchdowns has Isaac Guerendo scored?
Isaac Guerendo has 4 touchdowns in the regular-season games on file (4 rushing).
What is Isaac Guerendo's ScoutIndex Rating?
Isaac Guerendo rated 51.5 for 2025, the 60th percentile among RBs (provisional or limited sample). Ratings run 0–99; about 60 is a league-average qualified starter.

Related players

Top teammates, last season on file

Drafted in round 4, 2024