ScoutIndex

CLE CLE

Isaiah McGuire

DE

Drafted 126th overall in the 4th round of the 2023 draft, Isaiah McGuire arrived from Missouri. He's currently with CLE, in his 4th season in the league. He posted a 60.0 ScoutIndex Rating last season, an above-average mark that placed him in the 76th percentile among DEFs.

Size

6'4", 268#

College

Missouri

Draft

Rd 4, 126th overall (2023)

Seasons

2023–2026

2026 ScoutIndex Rating · DEF

Methodology
72.7

91th percentile among DEFs

6 games

Splash plays×0.15-0.34
Pass rush×0.3+2.08
Ball skills×0.25-0.61
Run defense×0.2+1.93
Availability×0.1+1.07

Career (regular season)

SeasonTmSIGPass ydsPass TDRush ydsRush TDRecRec ydsRec TD
2026CLE72.76
2025CLE6015
2024CLE69.713
2023CLE75.82

Career profile

Isaiah McGuire has appeared in 36 regular-season games across 4 NFL seasons on file, all with CLE.

By the ScoutIndex Rating, his best qualified season was 2024: a 69.7, in the 89th percentile among DEFs that year.

2026 splits

regular season

2026 game log

WkOppLineScore
Week 1JAX—40.7
Week 2TB—59.1
Week 3CAR—93
Week 4PIT—76.6
Week 5NYJ—41.1
Week 6BAL—74.9

Isaiah McGuire — common questions

What position does Isaiah McGuire play?
Isaiah McGuire is listed as a DE.
Which teams has Isaiah McGuire played for?
In the seasons on file (1999 onward), Isaiah McGuire has played for CLE (2023–2026).
Where did Isaiah McGuire go to college?
Isaiah McGuire played college football at Missouri.
When was Isaiah McGuire drafted?
Isaiah McGuire was selected in round 4, 126th overall, of the 2023 NFL Draft.
How many touchdowns has Isaiah McGuire scored?
Isaiah McGuire has no rushing, receiving or passing touchdowns in the regular-season games on file.
What is Isaiah McGuire's ScoutIndex Rating?
Isaiah McGuire rated 72.7 for 2026, the 91st percentile among DEFs (provisional or limited sample). Ratings run 0–99; about 60 is a league-average qualified starter.

Related players

Top teammates, last season on file

Drafted in round 4, 2023

Also from Missouri